Jigneshpadia2002
Bioengineer
- Jun 4, 2005
- 69
Hi !
I was doing one experiment on Tangential Flow Filtration membrane and I was confused by the flow outputs with and without pressure.
My assumption was
For a close system: Input = Output
Feed flowrate = Permeate flowrate + Retentate flowrate
When I started the experiment without any retentate and permeate pressure at afixed pump flowrate of 50 ml/min. I was observing the feed pressure gauge reading to be 18 psi.
When I increased the pressure on retentate side to 20 psi. This reduced the retentate flow. It also increased the feed pressure gauge. The flowrate of the pump was not changed. If the above equation of Input = Output was correct than the total of permeate + retentate sould remain unchanged. However, I observed that the total flow was decreased by 12 ml/min.
I am assuming that the flow decay is due to increase in pressure on feed and retentate side but I am still not able to understand clearly. Can I quantify the flow decay and pressure increase relationship.
Thanks a lot....
I was doing one experiment on Tangential Flow Filtration membrane and I was confused by the flow outputs with and without pressure.
My assumption was
For a close system: Input = Output
Feed flowrate = Permeate flowrate + Retentate flowrate
When I started the experiment without any retentate and permeate pressure at afixed pump flowrate of 50 ml/min. I was observing the feed pressure gauge reading to be 18 psi.
When I increased the pressure on retentate side to 20 psi. This reduced the retentate flow. It also increased the feed pressure gauge. The flowrate of the pump was not changed. If the above equation of Input = Output was correct than the total of permeate + retentate sould remain unchanged. However, I observed that the total flow was decreased by 12 ml/min.
I am assuming that the flow decay is due to increase in pressure on feed and retentate side but I am still not able to understand clearly. Can I quantify the flow decay and pressure increase relationship.
Thanks a lot....